R11, 12, 13, 14 are way too large to source current into an LED. I suggest 220 ohms to start. What is the forward voltage (Vf) of the LEDs?
This doesn't look like a volume control to me. It looks like an electronic selector switch, selecting one of four stereo inputs to one stereo output. Is this correct?
When powered by nothing but +5V and GND, the 4053 has a very limited signal voltage amplitude range. To make sure your signal is not clipped, you need to provide a DC bias at the 4053 inputs to make sure the audio is centered at 2.5 V.
Without knowing what the output of the multiplexer is driving, the input R-C (for example, R7-C1) forms a 3.4 kHz highpass filter. What is the bandwidth of the signals you are switching?
Vcc and Vdd and two different net names. Most pcb layout software will not connect them together automatically. Also, you have the same ground symbol labeled both GND and Vss. Are these supposed to be the same net?
ak