It depends on the codec used to re-encode it.
If one with the same compression ratio as the original film is used, the quality could degrade noticeably but if a lower compression ratio is used it won't be too bad and if it's lossless it'll be perfect.
Try editing a JPG a couple of times and you'll notice the drop in quality each time it's saved because it's lossy, try doing the same with a PNG and it'll look as good as the original because it's lossless. Unfortunately a PNG takes more space.
The problem then becomes storing it but if it's a 50GB disc, it could easily be transferred to a 100GB disc and if it's 100GB, it could be transferred to two.
This is assuming if it's re-encoded if it's cracked and ripped directly, it'll be as good as the original and be the same size.