Yes.
The driver ICs are only switches and without the terminating resistors the bus voltages will not return to the idle state quickly.
It may work without termination for short busses but could be erratic and sensitive to noise.
CAN interface ICs are specifically for the CAN network protocol and are not really suitable for other data. They may not work at all or may be erratic.
If you want a general driver/receiver system for sending such as a PWM waveform, you are far better off using RS422 or RS485 type bus interface ICs. They still need termination for anything other than short cables, but are active in both logic states rather than relying on the termination for one state.