if you have a XY plotter with good resolution then it's just up to the ink, you could use some ink that is not washable, like the one in permanent markers wich can be cleaned by alchool or other stuff. i used to draw my pcb's with marker and the ink is resistent to the chemicals, but some markers have ink that is much stronger and can not be cleaned with alchool, and you need special paint cleaner. but that is the best i used.
but it would be even better if you could modify a laser printer ans directly print with resistent inl on the pcb.....imagine how simple it would be!!