Your .zip file is a bunch of Proteus-generated files to manufacture a PCB. If you "save as" or "print as" as .pdf and post the .pdf, more of use will be able to view it. I am not able to open .rar files and about 2 weeks ago spent a lovely evening getting rid of WINRar. Again, please post .pdf or .zip for maximum audience.
1. Distribute the components on the PCB.
2. Do a good routing planning
3. Check the tracks fit in the defined space
4. Separate the analog part of the digital part.
5. Route the tracks to 45 degrees.
6. Do "sneaking" to the traces
7. Define good retung path.
8.Put copper zones or ground planes to improve the performance of GND and PCB itself
9. Define a track width according to current and space according to voltage
10. Use Routing strategies (minimize usea of vias)
11. Using an adequate routing topology (star or flow)
12.Route the decoupling network optimal