depends on a few things, how much weight, how much vibration, how much thermal cycling. unless you have a big fan causing vibration, i wouldn't worry about it for over the weekend. as far as thermal cycling, it takes a long time for that to cause problems. i've seen stuff that's been running for 5-10 years and begins getting broken solder on the collector or drain lead. this is because the collector/drain heats up and the lead expands with heat, and contracts when powered off. the emitter/source and base/gate leads don't heat up as much, so the collector/drain lead pushes against the solder connection and eventually begins weakening the solder. so, if you've done a lot of repairs on older equipment, this is why it's usually the collector lead ending up with broken solder. it's kind of rare for the leads to break off inside the transistor, but it does occasionally happen. this is usually caused by vibration, or the PCB flexing.