The only source for fissionable elements, whether naturally occurring or forged from something else in a nuclear reactor, and any element heaver than Iron for that matter, is a super nova. Yup, you need to have a star explode at the end of it's fusion life to make any. Similarly, through fusion, you start with Hydrogen and can't go any heaver than, again, Iron and all the Hydrogen in the Universe, including much of the Helium and Lithium, was forged as the big bang cooled enough to permit atoms to exist.