I'm running Ubuntu 12.04 LTS from the live CD (runs in RAM) on a real system. I did install CUPS once, Issues without CUPS involve Duplex and Paper size not sticking/.
Printing issues in general arise when printing or printing to PDF the output of certain websites. Annoyances are, I can't look at what's below the print dialog and it doesn;t preview "Print to file". I might use a file name such as 180101_Amazon (Tape, pens)_(X0000)_20.40 For example. Date, who, (what), (How Paid, CC last 4 digits), amount.
I can't easily get the price and if a website messes up when printing, I can't tell.
CUPS adds a lot more features.