Tony is right...
Mixed signal often means "digital" signals and analog signals are on the same board.
Eg a digital comes signal and say a analog signal from a thermistor, on the same board.
RF is higher frequency and "weird" components, not the usual hobby stuff, start being needed.
Of course, all is really analog.
And in truth , we use low frequency approximations so that we don't have to use rf theory on our low freq analog stuff....because really , to be accurate we should use EM theory on all our circuits, but its impractical, so we approximate and who cares cuzz it gets the job done.