Yep, but there may not be a need to amplify it. Set the Vref for 2.048v resolution which will then be 2mV or 0.2'C resolution.
Then average 16 readings over a period of one mains cycle, so the few mV noise picked up by the mains is negated, BUT it also adds a +/- varying factor to the ADC volatge so when you average it you can get double the resoltuion with a fair degree of accuracy.
So you add 16 readings over a mains cycle, then divide the total by 8, (giving you double the resolution) so it is now at a resolution of 0.1'C.