atferrari , ignore Nigel, he has trouble with abstract thoughts.
I think it is safe to say you should design collector current a minimum of 10x to (preferably) 100x ABOVE the transistor cutoff current (see "collector cutoff current" on datasheet - usually listed next to "base cutoff current"). An ON Semi datasheet for 2N3904 lists 50nA as the cutoff current for both cutoffs so I would design the minimum current at 5uA.
But... like said, it USUALLY depends on other components and you design amplifiers around them. But if you are trying to design for micro power you have to examine questions like you ask here, do the same for each component or module and design around your most pressing constraints.
Also, you need to look into how:
- downstream modules load (draw current) from that collector, and
- other current leakages, like reverse currents, or dark currents that can dilute your collector signal with noise.
I would recommend you trying to track down the "Art of Electronics" and review the section on low current circuits.