Some where PWm for brightness is mentioned, so i have been advocating PWM on the GND. But hey its a Mr Deb thread, therefore the normal laws of physics are suspended until further notice.LEDs in series driven by a constant current source don't need to be well matched. The current through each LED will be exactly the same, regardless of Vf. The brightness may vary if they're not well matched. Power dissipation will vary too as Vf varies, but this shouldn't be an issue unless they are being driven at max power.
Opto-isolators are a good idea (provided they are placed in the right location) but you don't need an additional transistor to drive the module input pin that's designed to be driven by a microcontroller output. The output of the optoisolator is a transistor.
MrDEB hasn't said if he's planning to drive the modules with PWM to have brightness control. If that's his plan, I'm looking forward to seeing how he's going to drive ten(?) modules with a PIC18F-series.