Not unless your program is written in C. It sounds like you have installed a C compiler after MPLAB was installed and it has messed up the default tool suites. Uninstall the C compiler, then uninstall MPLAB (Yes I know; AGAIN!), reboot and reinstall MPLAB only. Then try it again. Put your *.asm file in a directory like this; C:\mplab\project1
Do NOT put it into MyDocuments because some systems with multi users create a VERY long path to MyDocuments even though it appears to be short in file explorer.