On the simpler side of things (to understand) there are two approaches to consider - a simple diode or crystal radio with a one tube audio amplifier following - that could be more than one stage. Another approach might be to use the tube to amplify the RF prior to the detector (diode) stage. A tube with several sections might be used to do both - a tuned rf stage followed by amplification of the detected audio. I mention these as alternatives though the regen approach seems most popular.