Something never done before, something innovative or maybe just an improved version of an existing device....
New trick #1: The Third Dimension and Six Degrees of Freedom
A standard mouse is a two dimensional input device. To move (translate) in 3D space, one needs three degrees of freedom (DOF) for x, y and z axes. If one also needs to rotate in 3D space, three additional degrees of freedom are needed. Although a variety of 6 DOF input devices have been developed and evaluated, it is appealing to develop a mouse-like 3D input device. There indeed have been many attempts along these lines.
New Trick #2: Making a Mouse "feel-able"
It is intuitive and appealing to add a sense of feel to computer interfaces. There are two classes of feel that can be incorporated into a mouse: vibration (texture) and resistive forces similar to those we experience in the physical world (force feedback). An example of such a "multimodal mouse" has been demonstrated. Recently Immersion Corp. (San Jose, CA) developed a commercial force feedback mouse with the trade mark Feelitä, although formal studies have yet to appear, such a mouse may enhance user performance when acquiring fine targets, such as a corner of a GUI window.
Of course the days of the mouse may be numbered, after all it's nearly thirty years old now. Gesture recognition is an emerging idea but to be honest I still like the idea of those Star Trek keyboards from the next generation.