Are you interested in the design/layout procedure, or more of the "administrative" side of things - how to specify the stuff for the fab house (i.e. the company that actually makes the boards)?
I've been using Protel99 for the last couple years (since I'm not quite happy about jumping into the whole license scheme they've implemented on the newer tools), so if you need any specific tips, feel free to ask.
Also, Protel99 is one of the cheaper packages, so I remember there being a lot of newsgroup/message board traffic concering it.