It is possible with any programmable logic device as long as the software used to synthesize the configuration supports VHDL. This includes any FPGA and CPLD from Xilinx and Altera (the two big names), as well as others like Lattice.
The practical real world use of VHDL is configuring programmable logic devices...not sure what you are trying to ask. It's like asking what is the real world use of C/C++.